Ongoing studies

At St.Claraspital we practice a patient-oriented research directly on and with the patient or test person. This practice includes clinical studies, but also epidemiological studies and case-control studies. Below is the study list of the current open oncological, haematological and metabolic studies.

Oncological studies

Abdomen Principal InvestigatorKoordinator

Biobanking Viszeral

Personalized analysis of intestinal cancer ex vivo and in vivo

M. von Strauss                

U. Ruscher


Distal Pancreatectomy – A randomised controlled trial to compare minimal-invasive
distal pancreatectomy to open resection (DISPACT-2 Trial)
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B. Müller              




Intelligent Vacuum assisted biopsy Immediately before Surgery as an Intra- or pre-Operative surrogate for patient response to Neoadjuvant chemotherapy for breast cancer. A multicenter prospective feasibility trial..
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M. Machacek           

C. Punsola          



Cancer diagnostics Principal InvestigatorCoordinator
4D_Liquid-Biopsies Prospective Evaluation of 4D LifetestTM Parameters to Develop a Universal Early Cancer Diagnosis Test    B. WölnerhanssenV. Pflimlin-Fritschy
EDIUMEDIUM / Outcome quality in colorectal cancer: identification of differences and measures for nationwide quality development. B. WölnerhanssenD. Engelen/ D. de Jong-Bakker
BERING CRCEncorafenib and cetuximab in patients with metastatic, BRAFV600E-mutated, colorectal carcinoma: a multi-centric, national, prospective, longitudinal, non-interventional study in Switzerland
M. Löffler-BaumannD. de Jong-Bakker
EOCC SnapshotSnapshot Audit on Early onset Colorectal Cancer - are we doing enough, can we do more?
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M. von Strauss/S. TahaB. Kammer
PROSAICPatient Reported Outcomes and Markers of Inflammation in Anal Cancer – a Longitudinal Observational Study (PROSAIC)
D. SteinemannD. de Jong-Bakker
NEORECTBiomarker Identification to guide surgical intervention after neoadjuvant chemoradiotherapy in rectal cancer (BSIRC)
M. von StraussU. Ruscher
IBDS-CRCEstablishment of a platform for analyzing the genetic profile and effect of cancer drugs in patients with colorectal cancer
D. KöberleC. Punsola



Lungs Principal InvestigatorCoordinator

Prospective and retrospective registry of patients with metastatic NSCLC harbouring typical and atypical EGFR mutations

Vonder Mühll-SchillB.Allmendinger
SAKK 16/18

Immune modulatory radiotherapy to enhance the effects of neoadjuvant PD L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III(N2) non small cell lung cancer (NSCLC). A multicenter phase II trial. 

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M. BuessB.Allmendinger

New tools to improve management of patients with suspected pneumonia
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S. SteuerC. Punsola


Ovaries Principal InvestigatorCoordinator

Aintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO). The purpose of this study is to evaluate the efficacy of the addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer).
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T. SchmidB. Allmendinger

Ovarian cancer data and treatment register

R. ZanettiB. Allmendinger
Palliative Care Principal InvestigatorCoordinator
SAKK 96/12 (Palliative care)

Prevention of Symptomatic Skeletal Events with Denosumab Administered Every 4 weeks versus every 12 Weeks – A Non-Inferiority Phase III Trial

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A. TempletonB.Allmendinger
Prostate Principal InvestigatorCoordinator
BEDNA-StudyBlood collection for the analysis of cell-free DNA in patients with advanced cancerT. ZellwegerD. de Jong-Bakker
Ex VivoFresh tissue ex-vivo: development of ex vivo models of prostate cancerT. ZellwegerD. de Jong-Bakker
PCO-CRVProstate Cancer Outcomes – Compare & Reduce Variation in Prostate Cancer Centers certified by the German Cancer SocietyT. ZellwegerK. Butz
ProBioIn our research project, we want to find out whether the selection of the drug depending on the genetic changes of the individual tumor (tumor signature) can lead to a better control of the tumor
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A. TempletonD. de Jong-Bakker
Testicles Principal InvestigatorCoordinator
SAG TCCSProspective data collection in patients with testicular cancerA. TempletonA. Templeton
Registry / observation studies Principal InvestigatorCoordinator
IMDCRegistry study on treatment of renal cell carcinoma with targeted therapy.A. TempletonD. de Jong-Bakker
SwissNETInformation collection for effective neuroendocrine tumor researchB. NiemannB. Allmendinger
Swiss MDS Study GroupData and sample collection for the discovery of new biological relationships, which also allow a description of the current status and future developments in diagnostics and therapy.S. ParmentierD. de Jong-Bakker
AXSANAA prospective multicenter cohort study to evaluate different surgical methods of axillary staging in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy.M. MachacekC. Punsola
Oesophagus Principal InvestigatorCoordinator
GASPERAssessment and Validation of Gastric Conduit Perfusion in Esophageal Reconstruction
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L. FourieV. Pflimlin
CARDIASurgery for adenocarcinoma of the gastroesophageal junction (GEJ) type II: Transthoracic esophagectomy vs. Transhiatal extended gastrectomy.
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B. MüllerB. Kammer

Esophagogastric adenocarcinoma. Defining the role of atezolizumab in the neoadjuvant treatment of oesophageal cancer.
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D. KöberleD. de Jong-Bakker


Metabolic and Gastroenterological Studies

Bariatric surgery

Gastric Bypass Principal InvestigatorCoordinator
SLIM part 1, 2 & 3Swiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery (SLIM trial)
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R. PeterliJ. Distler



Low Carb Program Principal InvestigatorCoordinator
LCP SinergiaUnderstanding gut-brain interactions and the effect of a low crab dietary intervention in obese patients with daibetes or glucose intoleance: a pilot trial.
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B. WölnerhanssenV. Bordier


Chronic Inflammatory Bowel Diseases

  Principal InvestigatorCoordinator
5C-StudyCholecalciferol Comedication in Patients with Chronic Inflammatory Bowel Diseases (Crohn's disease or ulcerative Colitis)
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P. HrúzV. Pflimlin-Fritschy


Contact Clara Research

St. Clara Forschung AG
Kleinriehenstr. 43
4058 Basel

Tel.: 061 685 85 85

Contact Clara Hospital

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T: 061 685 85 85