Ongoing studies

At St.Claraspital we practice a patient-oriented research directly on and with the patient or test person. This practice includes clinical studies, but also epidemiological studies and case-control studies. Below is the study list of the current open oncological, haematological and metabolic studies.

Oncological studies

Abdomen Principal InvestigatorKoordinator

Biobanking Viszeral

Personalized analysis of intestinal cancer ex vivo and in vivo

M. von Strauss                

U. Ruscher


Intelligent Vacuum assisted biopsy Immediately before Surgery as an Intra- or pre-Operative surrogate for patient response to Neoadjuvant chemotherapy for breast cancer. A multicenter prospective feasibility trial..
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M. Machacek           

G. Reinhard            



Cancer diagnostics Principal InvestigatorCoordinator
4D_Liquid-Biopsies Prospective Evaluation of 4D LifetestTM Parameters to Develop a Universal Early Cancer Diagnosis Test    B. WölnerhanssenV. Pflimlin-Fritschy
EDIUMEDIUM / Outcome quality in colorectal cancer: identification of differences and measures for nationwide quality development. B. WölnerhanssenD. Engelen/ G. Reinhard
IBDS-CRCImage-based ex vivo drug screening and genomics/transcriptomics for patients with colorectal cancer stage II, III or IV (IBDS-CRC).  D. KöberleG. Reinhard
PREVASCO trialBiomarker at CRC: Prospective sample collection for the evaluation of next generation colorectal cancer screening blood test,  Colox®, for the detection of advanced adenoma and colorectal cancer.B. WölnerhanssenV. Pflimlin-Fritschy
AIO-18.1Short-term radiotherapy versus radiochemotherapy followed by consolidative chemotherapy and selective organ preservation for patients with MRI-defined intermediate- and high-risk rectal cancer A randomized phase III German Rectal Cancer Group ACO/ARO/AIO-18 trial.1.
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W. Harms

D. de Jong-Bakker
BERING CRCEncorafenib and cetuximab in patients with metastatic, BRAFV600E-mutated, colorectal carcinoma: a multi-centric, national, prospective, longitudinal, non-interventional study in Switzerland
M. Löffler-BaumannG. Reinhard
PROSAICPatient Reported Outcomes and Markers of Inflammation in Anal Cancer – a Longitudinal Observational Study (PROSAIC)
D. SteinemannD. de Jong-Bakker
NEORECTBiomarker Identification to guide surgical intervention after neoadjuvant chemoradiotherapy in rectal cancer (BSIRC)
M. von StraussU. Ruscher
5C-StudyCholecalciferol Comedication in Patients with Chronic Inflammatory Bowel Diseases (Crohn's disease or ulcerative Colitis)

P. Hrúz

V. Pflimlin
Lungs Principal InvestigatorCoordinator

Prospective and retrospective registry of patients with metastatic NSCLC harbouring typical and atypical EGFR mutations

Vonder Mühll-SchillG. Reinhard
SAKK 16/18

Immune modulatory radiotherapy to enhance the effects of neoadjuvant PD L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III(N2) non small cell lung cancer (NSCLC). A multicenter phase II trial. 

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M. BuessG. Reinhard
Ovaries Principal InvestigatorCoordinator

Aintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO). The purpose of this study is to evaluate the efficacy of the addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer).
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T. SchmidC. Riggenbach
Palliative Care Principal InvestigatorCoordinator
SAKK 96/12 (Palliative care)

Prevention of Symptomatic Skeletal Events with Denosumab Administered Every 4 weeks versus every 12 Weeks – A Non-Inferiority Phase III Trial

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A. TempletonC. Riggenbach
Prostate Principal InvestigatorCoordinator
BEDNA-StudyBlood collection for the analysis of cell-free DNA in patients with advanced cancerT. ZellwegerG. Reinhard
Ex VivoFresh tissue ex-vivo: development of ex vivo models of prostate cancerT. ZellwegerG. Reinhard
PCO-CRVProstate Cancer Outcomes – Compare & Reduce Variation in Prostate Cancer Centers certified by the German Cancer SocietyT. ZellwegerG. Reinhard
ProBioIn our research project, we want to find out whether the selection of the drug depending on the genetic changes of the individual tumor (tumor signature) can lead to a better control of the tumor
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A. TempletonC. Riggenbach
Testicles Principal InvestigatorCoordinator
SAG TCCSProspective data collection in patients with testicular cancerA. TempletonC.Riggenbach
Registry / observation studies Principal InvestigatorCoordinator
IMDCRegistry study on treatment of renal cell carcinoma with targeted therapy.A. TempletonC.Riggenbach
SwissNETInformation collection for effective neuroendocrine tumor researchB. NiemannC.Riggenbach
Swiss MDS Study GroupData and sample collection for the discovery of new biological relationships, which also allow a description of the current status and future developments in diagnostics and therapy.S. ParmentierD. de Jong-Bakker
AXSANAA prospective multicenter cohort study to evaluate different surgical methods of axillary staging in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy.M. MachacekD. de Jong-Bakker
Oesophagus Principal InvestigatorCoordinator
GASPERAssessment and Validation of Gastric Conduit Perfusion in Esophageal ReconstructionL. FourieV. Pflimlin
CARDIASurgery for adenocarcinoma of the gastroesophageal junction (GEJ) type II: Transthoracic esophagectomy vs. Transhiatal extended gastrectomy.L. FourieU. Ruscher


Metabolic Studies

Bariatric surgery

Gastric Bypass Principal InvestigatorCoordinator
SLIM part 1, 2 & 3Swiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery (SLIM trial)
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R. PeterliJ. Distler


Natural Sweeteners

Sugar metabolism: erythritol/ table sugar Principal InvestigatorCoordinator
EryAdoEffect of daily intake of erythritol versus table sugar for 5 weeks on sugar metabolism in adolescents: a pilot study.
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B.Wölnerhanssen, AC. Meyer-GerspachV. Bordier



Low Carb Program Principal InvestigatorCoordinator
LCP SinergiaUnderstanding gut-brain interactions and the effect of a low crab dietary intervention in obese patients with daibetes or glucose intoleance: a pilot trial.
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B. WölnerhanssenV. Bordier


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Kleinriehenstr. 43
4058 Basel

Tel.: 061 685 85 85

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T: 061 685 85 85