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Ongoing studies

At St.Claraspital we practice a patient-oriented research directly on and with the patient or test person. This practice includes clinical studies, but also epidemiological studies and case-control studies. Below is the study list of the current open oncological, haematological and metabolic studies.
 

Oncological studies

Breast   
Elasto TrialComparison of accuracy and reproducibility of breast lesion characterization between real time elastography and shear wave elastography.
Learn more		R. Zanetti DällenbachR. Zanetti Dällenbach
SAKK 23/16 (TAXIS)

Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with high risk node-positive breast cancer: A multicenter  randomized open labeled phase III trial (TAXIS)
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R. Zanetti DällenbachCh. Riggenbach
Eryt/CoordiFit         

Wirksamkeit von Bewegungstherapie gegen Fatigue (chronische Müdigkeit) bei Patientinnen mit metastasierter Brustkrebserkrankung.
Learn more

A. Templeton          G. Reinhard             
Cancer diagnostics Principal InvestigatorCoordinator
4D_Liquid-Biopsies Prospective Evaluation of 4D LifetestTM Parameters to Develop a Universal Early Cancer Diagnosis Test    B. WölnerhanssenV. Pflimlin-Fritschy
Colon   
PREVASCO trialBiomarker at CRC: Prospective sample collection for the evaluation of next generation colorectal cancer screening blood test,  Colox®, for the detection of advanced adenoma and colorectal cancer.B. WölnerhanssenV. Pflimlin-Fritschy
SAKK 41/13Adjuvant aspirin treatment in PIK3CA  mutated colon cancer patients. A randomized, double-blinded, placebo-controlled, phase III trial adjuvant
Learn more		D. KöberleC. Riggenbach
SAKK 41/16Neoadjuvant treatment with Regorafenib and Capecitabine combined with radiotherapy in locally advanced rectal cancer. A multicenter phase Ib trial (RECAP).
Learn more		D. KöberleC. Riggenbach
Lungs Principal InvestigatorCoordinator
SAKK 16/18

Immune modulatory radiotherapy to enhance the effects of neoadjuvant PD L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III(N2) non small cell lung cancer (NSCLC). A multicenter phase II trial. 

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M. BuessG. Reinhard
Ovaries Principal InvestigatorCoordinator
MATAO (ENGOT-ov54)

Aintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO). The purpose of this study is to evaluate the efficacy of the addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer).
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T. SchmidC. Riggenbach
Palliative Care Principal InvestigatorCoordinator
SAKK 96/12 (Palliative care)

Prevention of Symptomatic Skeletal Events with Denosumab Administered Every 4 weeks versus every 12 Weeks – A Non-Inferiority Phase III Trial

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A. TempletonC. Riggenbach
Pancreas Principal SAKK 44/19 
PDAC-IRE

Irreversible electroporation (IRE) followed by
nivolumab in patients with metastatic pancreatic
cancer: a multicenter single arm phase II trial

M. BolliC. Riggenbach
Prostate Principal InvestigatorCoordinator
BEDNA-StudyBlood collection for the analysis of cell-free DNA in patients with advanced cancerT. ZellwegerG. Reinhard
Ex VivoFresh tissue ex-vivo: development of ex vivo models of prostate cancerT. ZellwegerG. Reinhard
PCO-CRVProstate Cancer Outcomes – Compare & Reduce Variation in Prostate Cancer Centers certified by the German Cancer SocietyT. ZellwegerG. Reinhard
Testicles Principal InvestigatorCoordinator
SAG TCCSProspective data collection in patients with testicular cancerA. TempletonC.Riggenbach
Registry / observation studies Principal InvestigatorCoordinator
SAKK 80/19 Alpine TIRAlpine Tumor Immunology RegistryT. SchmidC. Riggenbach

Metabolic Studies

Bariatric surgery

Oesophagus Principal InvestigatorCoordinator
FUB A & BLong-term adverse effects after laparoscopic sleeve gastrectomy and Roux-Y-Gastric Bypass: Part A Bone and Part B Oesophagus
Learn more		B.Wölnerhanssen, AC. Meyer-GerspachU. Ruscher, A. Etter-Atlass

 

Gastric Bypass Principal InvestigatorCoordinator
SLIMSwiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery (SLIM trial)R. PeterliJ. Distler

 

Natural Sweeteners

Energy intake: Sucrose/ Erythritol/ Sucralos Principal InvestigatorCoordinator
PolyFoodIntakeEffects of oral pre-loads on subsequent energy intake, gastrointes-tinal hormones, glycemic control, appetite-related sensations, and gastrointestinal tolerance
Learn more		A.C. Meyer-GerspachF. Teysseire

Sweet receptors: D-Allulose/Erythritol Principal InvestigatorCoordinator
PolyAlluLacAcute effects of the two alternative sweeteners D-allulose and erythritol on gastrointestinal hormone secretion and glycemic control
Learn more		A.C. Meyer-GerspachF. Teysseire
Vascular function: Xylitol/Erythritol Principal InvestigatorCoordinator
PolyVascEffect of the natural sweeteners erythritol and xylitol on vascular function in obese volunteers: a pilot study
Learn more		B.Wölnerhanssen, AC. Meyer-GerspachV. Bordier

Nutrition

Low Carb Program Principal InvestigatorCoordinator
LCP SinergiaUnderstanding gut-brain interactions and the effect of a low crab dietary intervention in obese patients with daibetes or glucose intoleance: a pilot trial.
Learn more		B. WölnerhanssenV. Bordier

 

COVID-19 studies

  Principal InvestigatorCoordinator
HostDx Covid-19HostDx™-ViralSeverity: a COVID-19 prognostic toolS. VesenbeckhU. Ruscher
Long Covid-19Prospective Observational Cohort Study to Investigate Long-term Pulmonary and Extrapulmonary Effects of COVID-19S. Ottn.a.

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forschung@claraspital.ch

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