Ongoing studies

At St.Claraspital we practice a patient-oriented research directly on and with the patient or test person. This practice includes clinical studies, but also epidemiological studies and case-control studies. Below is the study list of the current open oncological, haematological and metabolic studies.
 

Oncological studies

Abdomen Principal InvestigatorKoordinator

Biobanking Viszeral

Personalized analysis of intestinal cancer ex vivo and in vivo

S. Staubli                

U. Ruscher

Breast   
Eryt/CoordiFit         

Efficacy of exercise therapy for fatigue (chronic fatigue) in patients with metastatic breast cancer.
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A. Templeton          G. Reinhard             
Cancer diagnostics Principal InvestigatorCoordinator
4D_Liquid-Biopsies Prospective Evaluation of 4D LifetestTM Parameters to Develop a Universal Early Cancer Diagnosis Test    B. WölnerhanssenV. Pflimlin-Fritschy
Colon   
EDIUMEDIUM / Outcome quality in colorectal cancer: identification of differences and measures for nationwide quality development. B. WölnerhanssenD. Engelen/ G. Reinhard
Wicki-Studie (IBDS-CRC)Image-based ex vivo drug screening and genomics/transcriptomics for patients with colorectal cancer stage II, III or IV (IBDS-CRC).  D. KöberleG. Reinhard
PREVASCO trialBiomarker at CRC: Prospective sample collection for the evaluation of next generation colorectal cancer screening blood test,  Colox®, for the detection of advanced adenoma and colorectal cancer.B. WölnerhanssenV. Pflimlin-Fritschy
AIO-18.1Short-term radiotherapy versus radiochemotherapy followed by consolidative chemotherapy and selective organ preservation for patients with MRI-defined intermediate- and high-risk rectal cancer A randomized phase III German Rectal Cancer Group ACO/ARO/AIO-18 trial.1.
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D. de Jong-Bakker 
Lungs Principal InvestigatorCoordinator
SAKK 16/18

Immune modulatory radiotherapy to enhance the effects of neoadjuvant PD L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III(N2) non small cell lung cancer (NSCLC). A multicenter phase II trial. 

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M. BuessG. Reinhard
Ovaries Principal InvestigatorCoordinator
MATAO (ENGOT-ov54)

Aintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO). The purpose of this study is to evaluate the efficacy of the addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer).
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T. SchmidC. Riggenbach
Palliative Care Principal InvestigatorCoordinator
SAKK 96/12 (Palliative care)

Prevention of Symptomatic Skeletal Events with Denosumab Administered Every 4 weeks versus every 12 Weeks – A Non-Inferiority Phase III Trial

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A. TempletonC. Riggenbach
Pancreas Principal Investigator 
PDAC-IRE

Irreversible electroporation (IRE) followed by
nivolumab in patients with metastatic pancreatic
cancer: a multicenter single arm phase II trial

M. BolliC. Riggenbach
Prostate Principal InvestigatorCoordinator
BEDNA-StudyBlood collection for the analysis of cell-free DNA in patients with advanced cancerT. ZellwegerG. Reinhard
Ex VivoFresh tissue ex-vivo: development of ex vivo models of prostate cancerT. ZellwegerG. Reinhard
PCO-CRVProstate Cancer Outcomes – Compare & Reduce Variation in Prostate Cancer Centers certified by the German Cancer SocietyT. ZellwegerG. Reinhard
Testicles Principal InvestigatorCoordinator
SAG TCCSProspective data collection in patients with testicular cancerA. TempletonC.Riggenbach
Registry / observation studies Principal InvestigatorCoordinator
IMDCRegistry study on treatment of renal cell carcinoma with targeted therapy.A. TempletonC.Riggenbach
SwissNETInformation collection for effective neuroendocrine tumor researchB. NiemannC.Riggenbach
Swiss MDS Study GroupData and sample collection for the discovery of new biological relationships, which also allow a description of the current status and future developments in diagnostics and therapy.S. ParmentierD. de Jong-Bakker

Metabolic Studies

Bariatric surgery

Oesophagus Principal InvestigatorCoordinator
FUB A & BLong-term adverse effects after laparoscopic sleeve gastrectomy and Roux-Y-Gastric Bypass: Part A Bone and Part B Oesophagus
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B.Wölnerhanssen, AC. Meyer-GerspachU. Ruscher

 

Gastric Bypass Principal InvestigatorCoordinator
SLIMSwiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery (SLIM trial)R. PeterliJ. Distler

 

Natural Sweeteners

Sugar metabolism: erythritol/ table sugar Principal InvestigatorCoordinator
EryAdoEffect of daily intake of erythritol versus table sugar for 5 weeks on sugar metabolism in adolescents: a pilot study.
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B.Wölnerhanssen, AC. Meyer-GerspachV. Bordier

 

Reward system: Erythritol Principal InvestigatorCoordinator

PolyReward

To evaluate the effects of orally administered beverages on the reward system, gastrointestinal hormone release, blood glucose metabolism, appetite sensation, and mood state.
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AC. Meyer-Gerspach

F. Teysseire, E. Flad

 

Nutrition

Low Carb Program Principal InvestigatorCoordinator
LCP SinergiaUnderstanding gut-brain interactions and the effect of a low crab dietary intervention in obese patients with daibetes or glucose intoleance: a pilot trial.
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B. WölnerhanssenV. Bordier

 

Contact Clara Research

St. Clara Forschung AG
Kleinriehenstr. 43
4058 Basel

Tel.: 061 685 85 85
forschung@claraspital.ch

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T: 061 685 85 85