Current studies

Research provides scientifically proven answers to medical questions and thus contributes to the improvement of medical care.

Clinical studies are conducted directly on and with the patient. This can be very different. For example, by testing the effect or dosage of a drug or by comparing different treatment methods for an indication. Numerous studies are currently being conducted at St. Clara Forschung AG.

Abdominal wall/groin

Perioperative Outcome (Pain, Complications, Duration of Hops) in MIS for ventral hernie repair over 2 years. Extraperitoneal plasty vs. intraperitoneal onlay mesh in ventral hernia repair - the randomized controlled ALPINE trial

Current studies

Blood and lymphatic system

Multicentre Observational Study of MDS Patients in Switzerland - Swiss MDS Registry

Current studies

Breast (mamma)

A prospective multicentre cohort study to evaluate different surgical methods of axillary staging in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy (EUBREAST 03 (R) AXSANA)

Methods for Localisation of Different types of breast lesions (EUBREAST 04 (R) MELODY)

Protocol SAKK 96/12 Prevention of Symptomatic Skeletal Events with Denosumab Administered every 4 Weeks versus every 12 Weeks - A Non-Inferiority Phase III Trial

Intelligent Vacuum assisted biopsy Immediately before Surgery as an Intra- or pre-Operative surrogate for patient response to Neoadjuvant chemotherapy for breast cancer (VISION I) A multicentre prospective feasibility trial

ARTIDIS: Physical structure change measurement in breast cancer

Current studies

Intestine

Outcome quality in colorectal cancer: Identification of differences and measures for nationwide quality development (EDIUM)

Image-based ex-vivo drug screening and genomics/transcriptomics for patients colorectal cancer stage II, III, IV (IBDS-CRC)

Patient Reported Outcomes and Markers of Inflammation in Anal Cancer - a Longitudinal Observational Study (PROSAIC)

Biomarker identification to guide surgical intervention after neo-adjuvant chemoradiotherapy in rectal cancer (BSIRC)

Selective neoadjuvant therapy in patients with locally advanced rectal cancer: SELREC – an open-label, randomized controlled, multicenter non-inferiority study

Current studies

Kidney

Metastatic Renal Cell Cancer: A Multicentre Prognostic and Predictive Factors Project in the Era of Modern Therapy (The International mRCC Database Consortium (IMDC))

Current studies

Lungs

SAKK_LuCa_2: Retrospective and prospective registry of patients with metastatic NSCLC harbouring typical and atypical EGFR mutations

SAKK 16/18: Immune-modulatory radiotherapy to enhance the effects of neoadjuvant PD-L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III(N2) non-small cell lung cancer (NSCLC). A multicentre phase II trial.

Current studies

Nutrition/overweight

Swiss Multicentre Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery (SLIM trial)

Understanding gut-brain interactions and the effect of a lowcarb dietary intervention in obese and depressive patients with and without glucose intolerance or diabetes: a pilot trial

Current studies

Ovaries

MAintenance therapy/maintenance therapy with aromatase inhibitors for patients with epithelial ovarian cancer: a randomised double-blind placebo-controlled multicentre phase III study. (ENGOT-ov54/Swiss-GO-2/MATAO)

SAKK_OvCaR: A retrospective and prospective registry of patients with ovarian cancer

Current studies

Pancreas

Distal Pancreatectomy - A randomised controlled trial to compare minimally-invasive distal pancreatectomy to open resection (DISPACT-2 Trial)

Current studies

Prostate

Blood sampling to analyse cell-free DNA in patients with advanced cancer (BEDNA study)

Development of ex vivo models of prostate carcinoma

Prostate Cancer Outcome - Compare and Reduce Variation in DKG Prostate Cancer Centres (PCO-CRV)

An outcome-adaptive and randomised multi-arm biomarker driven study in patients with metastatic prostate cancer (ProBio)

Protocol SAKK 96/12 Prevention of Symptomatic Skeletal Events with Denosumab Administered every 4 Weeks versus every 12 Weeks - A Non-Inferiority Phase III Trial

Current studies

Stomach and oesophagus

Personalised analysis of intestinal cancer ex-vivo and in-vivo

CARDIA Trail: Surgery for Adenocarcinoma of the Gastroesophageal Junction (GEJ) Type II: Transthoracic Esophagectomy vs. Transhiatal Extended Gastrectomy

Current studies

Testicles

Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS)

Current studies

Other

Personalised analysis of intestinal cancer ex-vivo and in-vivo

Collection of information for effective research into neuroendocrine tumours (SwissNET)

The influence of supervision on the completion of questionnaires on quality of life in cancer patients receiving systemic antineoplastic therapy (IMSUP)